The 16th European Microscopy Congress 2016
Fractals in the nucleus – understanding chromatin organisation with 3D SMLM
Abstract Chromatin presents a unique challenge in structural biology. Its fundamental units, DNA and the nucleosome, are well-characterised at the Ångstrom level.1 Yet, the higher-order…The 16th European Microscopy Congress 2016
Local order and conformation of nucleosomes in solution and in interphase nuclei analysed by cryo-electron microscopy of vitreous sections
Despite spectacular advances in our knowledge of chromosome dynamics and large scale organisation, little is still known about how the 10 nm nucleosome bead-on-string fibre…The 16th European Microscopy Congress 2016
Lipidic structures in the cell nucleus – role of lamins?
Spatial ordering of the cell nucleus is critical for controlling fundamental nuclear processes such as gene expression, DNA replication, and RNA processing. So far, mostly…