Articles tagged "antiobiotics"

The 16th European Microscopy Congress 2016
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Alexander Myasnikov (1, 2, 3), Kundhavai Natchiar (1, 2, 3), Marielle Nebout (4, 5), Isabelle Isabelle Hazemann (1, 2, 3), Véronique Imbert (4, 5), Heena Khatter (1, 2, 3), Jean-François Peyron (4, 5), Bruno Klaholz (1, 2, 3)
1. Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Illkirch, France 2. Centre National de la Recherche Scientifique, CNRS, UMR 7104, Illkirch, France 3. Institut National de la Santé et de la Recherche Médicale, INSERM, U964, Illkirch, France 4. Centre Méditerranéen de Médecine Moléculaire (C3M), INSERM, UMR 1065, Nice, France 5. UFR Médecine, Faculté de Médecine, Université de Nice-Sophia Antipolis, Nice, France
Abstract Many antibiotics in clinical use target the bacterial ribosome by interfering with several mechanistic steps of the protein synthesis machinery. However, targeting the human…