This contribution is devided in two sections. The first section is devoted to examine some relevant issues regarding force microscopy imaging of biomolecules such as spatial resolution, molecule deformation and quantitative mapping of mechanical properties. Specifically, we present a method to obtain the stress-strain curve of a single protein in liquid. The second section is devoted to present an advanced AFM method to genearte three dimensional maps of solid-liquid interfaces. We develop a force microscope method to map the 3D structure of solid-liquid interfaces. The maps provide atomic-scale spatial resolution images of the formation of hydration layers and the adsorption of ions on solid-liquid interfaces. Some applications include to resolve the atomic structure of hydration layers generated from alkali chloride solutions on an atomically flat mica surface.
D. Martin-Jimenez, E. Chacon, P. Tarazona, R. Garcia, Submitted
E.T. Herruzo, A.P. Perrino and R. Garcia, Nature Commun. 5, 3126 (2014)
R. Garcia, E.T. Herruzo, Nat. Nanotechnol. 7, 217-226 (2012)
To cite this abstract:Ricardo Garcia; Three-dimensional nanomechanical spectroscopy of soft matter-liquid interfaces. The 16th European Microscopy Congress, Lyon, France. https://emc-proceedings.com/abstract/three-dimensional-nanomechanical-spectroscopy-of-soft-matter-liquid-interfaces/. Accessed: December 5, 2022
EMC Abstracts - https://emc-proceedings.com/abstract/three-dimensional-nanomechanical-spectroscopy-of-soft-matter-liquid-interfaces/