Diabetes Mellitus is characterized by hyperglycemia resulting from abnormalities in insulin secretion, insulin action, or both. It is one of the most serious challanges of 21th century because of both increased prevalence due to industrialization, urbanization and changed lifestyle habits, and socio-economic impacts. Lifestyle reforms, treatment of oral antidiabetics for glycemic control and of statins to improve the dyslipidemia are crucial in the prevention and treatment of cardiovascular diseases caused by diabetes. Numerous studies proved that diabetes has negative effects on male reproductive system, however, data obtained about atorvastatin and gliclazide are conflicted.
In this study diabetes was induced in 250-300g young adult male Sprague-Dawley rats by streptozotocin. Diabetic rats were given atorvastatin, gliclazide and atorvastatin/gliclazide combination by oral gavage for 28 days. Rats were sacrificed on day 28 and hormone analysis in heart blood, morphological evaluations in sperms, light microscopic and ultrastructural examinations in testes were conducted. The obtained data were analyzed by using one-way ANOVA.
The following results were obtained: (i) diabetes and individually the drugs did not change the hormone levels, while atorvastatin/gliclazide combination reduced the testosterone level, (ii) diabetes decreased sperm count, altered sperm morphology, caused damage in testes and impaired spermatogenesis, (iii) in diabetic rats atorvastatin did not effect sperm count and not improve testes structure, yet ameliorated sperm morphology, (iv) in diabetic rats gliclazide increased sperm count, ameliorated sperm morphology, improved testes structure and spermatogenesis, (v) in diabetic rats atorvastatin/gliclazide combination did not effect sperm count, ameliorated sperm morphology, improved testes structure, however, the improvement has not reached to control level.
In conclusion, data obtained from the study, which the effects of atorvastatin and gliclazide combination in diabetes-induced damage on male reproductive system were evaluated, is believed to contribute to the literature.
To cite this abstract:Ezgi Öztaş, Tuğba Ekiz Yılmaz, Elif Güzel, Gül Özhan; Investigation on Effects of Atorvastatin and Gliclazide Combination Therapy on Male Reproductive System on Streptozotocin-Induced Diabetic Rats. The 16th European Microscopy Congress, Lyon, France. https://emc-proceedings.com/abstract/investigation-on-effects-of-atorvastatin-and-gliclazide-combination-therapy-on-male-reproductive-system-on-streptozotocin-induced-diabetic-rats/. Accessed: February 23, 2019
EMC Abstracts - https://emc-proceedings.com/abstract/investigation-on-effects-of-atorvastatin-and-gliclazide-combination-therapy-on-male-reproductive-system-on-streptozotocin-induced-diabetic-rats/