Measles a one of the most contagious human diseases. Last year we determined the structure of the helical nucleocapsid formed by the folded domain of the measles virus nucleoprotein encapsidating an RNA at 4.3 Å resolution (Gutsche et al, Science 2015). This structure revealed the molecular determinants of the nucleoprotein packing into a helix and provided first insights into the mode of nucleoprotein-RNA interaction in the nucleocapsid. We will now present our most recent high resolution cryoEM dataobtained with the goal to gain more precise structural information about the rationale of the RNA encapsidation.
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To cite this abstract:
Irina Gutsche, Ambroise Desfosses, Gregory Effantin, Wai Li Ling, Rob WH Ruigrok, Carsten Sachse, Guy Schoehn; CryoEM offers novel insights into the nucleoprotein-RNA interaction in the measles virus nucleocapsids. The 16th European Microscopy Congress, Lyon, France. https://emc-proceedings.com/abstract/cryoem-offers-novel-insights-into-the-nucleoprotein-rna-interaction-in-the-measles-virus-nucleocapsids/. Accessed: December 3, 2023« Back to The 16th European Microscopy Congress 2016
EMC Abstracts - https://emc-proceedings.com/abstract/cryoem-offers-novel-insights-into-the-nucleoprotein-rna-interaction-in-the-measles-virus-nucleocapsids/