Characterization and Preparation of Carvacrol Loaded Solid Lipid Nanoparticles and Imaging with Scanning Electron Microscopy (SEM)
Gökhan DIKMEN1*, Ilknur DAG2, Bukay YENICE GURSU3
1,2,3Eskisehir Osmangazi University, Central Research Laboratory Application and Research Center (ARUM), Odunpazarı, 26480, Eskisehir-Turkey
gokhandikmen1@gmail.com
Backgrounds: Drug carrier systems such as nano lipid particles, polymeric micelles, dendrimers and solid lipid nanoparticles (SLNs) provide controlled release of the drug both in the desired time and in specific region. A lot of anti cancerogen and anti microbial drugs such as carvacrol exhibit various side effects due to especially high dosage. These side effects can be eliminated using drug delivery systems such as SLNs and NLPs.
Material and methods: SLN formulations were prepared using hot homogenization method after then these formulations were characterized by Zeta Sizer, FT-IR, NMR and SEM. In order to image of SLN formulations, formulations were coated with Au-Pd complex and than imaged by SEM.
Results: Carvacrol loaded SLNs formulations were proven good stability (-34.4 mV) and small size (almost 190 nm). SLN formulations were compared with the freshly prepared formulations of carvacrol and tween 80 by FT-IR spectroscopy. In FT-IR spectra, any chemical shift or deformation in the bands and any stability problems were not observed. Moreover, SEM images were taken and measured the particle size of these formulations.
Conclusions: Particle size of Carvacrol was decreased using solid lipid nanoparticles and this formulation may be suitable as a nano drug carrier system for cancer and microbial treatment.
Keywords: Carvacrol, SLNs, SEM, Caharcterization, Spectroscopy
Acknowledgment: This work was supported by a grant from Eskisehir Osmangazi Universty (Project Number: 2015-910).
Figures:
SEM image of carvacrol loaded SLNs
To cite this abstract:
GOKHAN DIKMEN, ILKNUR DAG, BUKAY YENICE GURSU; Characterization and Preparation of Carvacrol Loaded Solid Lipid Nanoparticles and Imaging with Scanning Electron Microscopy (SEM). The 16th European Microscopy Congress, Lyon, France. https://emc-proceedings.com/abstract/characterization-and-preparation-of-carvacrol-loaded-solid-lipid-nanoparticles-and-imaging-with-scanning-electron-microscopy-sem/. Accessed: December 2, 2023« Back to The 16th European Microscopy Congress 2016
EMC Abstracts - https://emc-proceedings.com/abstract/characterization-and-preparation-of-carvacrol-loaded-solid-lipid-nanoparticles-and-imaging-with-scanning-electron-microscopy-sem/